NUST MISIS researchers have created nanoparticles for MRI that can visualize brain, breast, intestinal tumors, as well as predict the effectiveness of anticancer therapy, candidate of chemical sciences, head of the “Biomedical Nanomaterials” laboratory, an employee of NUST MISIS. department of medical nanobiotechs told Gazeta.ru RNIMU. NI Ministry of Health of the Russian Federation Maxim Abakumov Pirogov.
“Before a person is prescribed treatment, diagnostic nanoparticles can be made that can be injected and can see if they will penetrate the tumor. If your answer is yes, then the person may already be offered treatment with therapeutic nanoparticles. If not, it’s an expensive drug and most importantly the patient’s time for clearly ineffective treatment. provides prerequisites so as not to waste, ”explained Abakumov.
The concept of drug delivery to the tumor using nanoparticles is based on the so-called increased permeability and retention by tumor vessels.
“Normally we have a vascular network that supplies oxygen to all our organs. And when the tumor begins to grow, these vessels are formed with pathological defects. Some pores, dead ends, loops appear there. Nanoparticles are large enough to enter these pores. Healthy tissue does not have these pores, and nanoparticles penetrate there worse. If we see an accumulation of nanoparticles, this is most likely where the tumor is,” the expert said.
Giving a person a drug based on nanoparticles will not work if the pores are not visible in the modified vascular network.
Learn more about how nanoparticles are used to enhance the effectiveness of drugs, control mice, and incinerate cancerous tumors. material “socialbites.ca”.