Scientists have proposed a method for 3D printing tablets for controlled drug release. This was reported by the press service of the Max Planck Community Informatics Institute.
The most important parameter in the drug treatment of various diseases is the concentration of the active substance in the blood and tissues. It should be at the optimum level, not above or below. One solution is to produce complex shaped tablets that dissolve at varying rates but are very difficult to manufacture.
Wahid Babai and colleagues have proposed a technology for creating a substrate for such drugs using a 3D printer. The rate of release of the drug from it depends only on the chosen form – for example, the patient can initially take a large dose, then the residue will slowly dissolve, maintaining the concentration. The shape of the tablets was chosen using mathematical modeling, as it is nearly impossible to manually match a given dissolution curve. Using 3D printing in production can significantly reduce its cost.
The authors hope their discovery will significantly improve pharmacology.
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