Scientists at the University of California, Irvine, found that “blocking” the SAPS3 protein allowed mice to maintain a normal metabolism on a high-fat diet. Research published Nature Communication.
Biologists focused on a protein complex called AMPK, which is involved in controlling the energy balance of orgasm. For example, when blood sugar levels are low, AMPK can speed up the breakdown of fats for energy. Scientists know that eating large amounts of fat inhibits AMPK activity, which leads to metabolic imbalance. However, how cells block this mechanism has not yet been fully investigated.
Scientists have suggested that an AMPK component called SAPS3 plays an important role in this process. They tried to block SAPS3 in mice and fed them a 45% fat diet.
This allowed the mice to maintain a normal energy balance despite eating large amounts of fat. They maintained their normal weight, avoiding the development of obesity and diabetes.
Researchers began to create molecules that could inhibit SAPS3 and restore normal metabolism.