Bioinformatics from the Institute of Biomedical Chemistry. VN Orekhovich (IBMH) announced the creation of a new method for diagnosing the health of the human body, which determines the individual deviation from the general molecular “portrait” of a healthy person. This was reported to socialbites.ca by the Ministry of Science and Higher Education of the Russian Federation.
The description of the overall molecular portrait was compiled using the unique Avogadro scientific installation, the only molecular detector complex in Russia to study biosystems at the level of single molecules. A meta-analysis of human plasma was performed to establish a set of reference standards that could be used for health analysis. The scientists analyzed 53 of the 296 proteins that make up the “stable” part of a healthy person’s proteome—the set of body proteins produced by a cell, tissue, or organism over a period of time.
“Thus, we have created a kind of “proteomic signature of health,” or a reference, that can serve as a warning signal to adjust lifestyle, nutrition, and other factors to prevent disease,” said Elena Ponomarenko.
This approach makes it possible not only to detect proteins in the biomaterial, but also to determine their amount critical for medical use.
Compared with the antibody methods traditionally used in clinical diagnosis (especially enzyme-linked immunosorbent test – ELISA), the new method is more accurate and can give early warning of the onset of serious diseases. The experience gained within the framework of the project will form the basis of fundamentally new diagnostic systems of domestic production.
“The similarity of an individual portrait to a general portrait is evaluated by mathematical algorithms. As a result, the analysis system publishes a recommendation for adjusting lifestyle, taking into account the individual characteristics of a person, ”says Ekaterina Ilgisonis, head of the post-genomic data analysis laboratory.