Biologists have determined the mechanism of functioning of TBM macrophages, the violation of which causes autoimmune diseases. In this respect informs TASS.
A number of diseases such as type 1 diabetes and lupus occur without any pathogens or injuries as a result of internal problems in the body. In such cases, the person’s natural immunity is violated, and the body’s “defense” begins to attack its own tissues. The exact cause of such pathologies is unknown, it can be affected by both viruses and genetic disorders. For a long time, it was believed that CPC macrophages, the immune organs that use dead cells of the immune system, whose death occurs during the production of antibodies to infectious agents in the lymph nodes, play a decisive role in the development of autoimmune diseases. Without the collection of dead B cells, an inflammatory response occurs that can cause the immune system to attack healthy tissue.
For the first time, Phan Tri Giang and colleagues monitored the activity of CPC cells in the lymph nodes of live mice. To conduct such experiments, the scientists modified the rodent’s genome in such a way that their macrophages produced a red glow. These flashes of light were watched by scientists using a two-photon microscope that can get ultra-clear images of bright objects.
The researchers’ observations showed that CPC cells behave quite differently from other types of macrophages. They do not chase dying B cells like macrophages, which destroy microbes, but distribute evenly to the lymph nodes and catch dead bodies approaching them.
In the future, the scientists plan to make observations of CPC cells in mice with a human lupus analog.
previous experiment refuted the presence of macaque belief in justice.