The appearance of tumor cells may be associated not with “non-repair” of the genome, but with its low quality. In this respect informs TASS, referring to the press service of Moscow Phystech (MIPT).
For a long time, scientists believed that cancer was caused by the body’s inability to repair DNA errors. It was believed that this led to the uncontrolled division of cancer bodies, which accumulated more and more mutations.
Russian biologists have found signs that this view may be wrong. To do this, they examined the course of DNA repair in the nine most common cancers, including breast, lung, kidney, stomach, thyroid, and pancreas. Analysis by the researchers showed that most tumor types are characterized by increased rather than suppressed functioning of most DNA repair systems. As a result, tumor cells actively corrected errors that occurred during their division and vital activity, which contradicted established ideas about the behavior of cancer bodies.
At the same time, the study pointed to another possible cause of cancer – the quality of which is very likely to decrease with the increase in DNA repair efficiency. In cancer cells, the G2/M system, which controls the correctness of the corrections made in the DNA structure, restores the integrity of the helix and plays the role of a control mechanism that forces the cell to stop dividing, is suppressed. the presence of serious errors in the structure of the genome.
Without this control mechanism, tumor cells divide faster and accumulate mutations faster. The study’s authors hope that their findings can be used to create a new type of anti-cancer therapy that will reactivate G2/M.
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