Scientists from the University of Calgary have discovered a mechanism that increases the risk of developing a deadly fungal infection with coronavirus and flu. The results of the research were published in the journal Science Translation Medicine.
Humans inhale hundreds to thousands of fungal spores Aspergillus every day. To healthy people, fungi usually do not pose a threat, but in people with weakened immune systems, they can cause deadly infections. Viral infections can increase the risk of infection Aspergillus even in healthy people.
In a new study, scientists have discovered that it destroys previously unknown natural immunity needed to resist fungal infections of influenza and COVID-19. In experiments on mice and human blood and tissue samples, biologists have shown that two types of white blood cells (neutrophils and a unique type of B cell) often work together to fight fungal infection. SARS-CoV-2, or influenza, prevents B cells from destroying fungi by interacting with neutrophils.
The authors said their research began with the death of a young patient they were treating. The patient died of flu-associated aspergillosis, with no known treatments working. The results of their work will not only develop a cure, but also more effectively diagnose and prevent infections.