Neuroscientists at the University of Miami have found that hydrogen peroxide responds to EGFR (a protein that stimulates cell growth and cell differentiation of the epithelial lining via the epidermal growth factor receptor) in the skin, promoting wound healing and nerve cell regeneration. The researchers’ job was: published in the journal PNAS.
Scientists used zebrafish, whose genome is 70% similar to humans. Scientists were also interested in their ability to regenerate.
The team investigated how hydrogen peroxide stimulated nerve regeneration. Using zebrafish protein fluorescent labeling and mutant analysis, they reproduced a frame-by-frame visualization of this process.
“Frame-by-frame imaging provides a detailed understanding of biological processes and the relationships between nerves and skin, and how these interactions lead to regeneration,” the scientists said.
It turns out that hydrogen peroxide reacts to the EGFR receptor in the skin, which is necessary for skin remodeling and promotes nerve growth in the wound.
“We found that neurons cannot regenerate without the production of hydrogen peroxide. This component appears to be essential for coordinating the regeneration of nerve endings at the site of injury,” the scientists say.
According to the scientists, their work will help improve existing methods for treating skin sensitivity after wounds.
Source: Gazeta
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