Scientists from the University of Michigan found that insulin -producing pancreas contain abnormal mitochondria patients with diabetes in beta cells. The elimination of such damage by using the ISRIB drug normalizes insulin secretion and reduces blood sugar. Research Results published In Science magazine.
Mitochondria are the structures necessary for energy production that feeds cells and helps them function. Mitochondria defects are associated with the development of many diseases, including the second type of diabetes.
Studies have shown that with this disease, abnormal mitochondria of beta cells could not produce energy, which could not synthesize sufficient amount of insulin or use it to maintain normal blood sugar levels. However, these scientific studies could not explain why the cells behaved in this way.
Researchers from the United States found that the main cause of dysfunction of Bita-Cells mitochondria was a special stress reaction. The team repeated the experiments of mice on liver cells and adipose tissue, and that a similar reaction does not allow normal development and not only the endocrine system.
As part of experimental treatment, scientists used a drug called ISRIB that prevented the stress reaction. The result was the restoration of the functions of beta cells and the normalization of blood sugar within four weeks.
Now scientists are working on further work on corrupted cellular processes and are preparing to reproduce the results on examples of people with diabetes. Researchers hope that the elimination of cellular stress in the future can be used as a method of diabetes therapy in the future.
Previously Announced Overweight development mechanism of diabetes.
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Source: Gazeta
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