Scientists revealed the aging mechanism of proteins 15:48

Researchers from London Royal College found that chromatin, a structure of DNA and proteins, was more resistant to the aging processes of aging. This can help to understand how the body cope with age changes and which parts of the most vulnerable. Published in İş Magazine American Chemical Association Magazine (JACS).

Chromatin -forming proteins are subjected to changes in natural age. Stretched, distorted and are also subjected to chemical transformations -So -Traranslatal modicies. These changes may violate the work of proteins and in some cases lead to the development of diseases such as cancer.

However, due to the slow nature of the aging process, it is difficult to examine the age -related changes in the body’s proteins. To overcome this problem, scientists reconstructed artificial chromatin in the test tube at different stages of the life cycle: “young” and “old”, including translative modifications, characteristic of aging.

The analysis has shown that despite local changes associated with age -related modifications, the general structure and integrity of chromatin was not practically violated. However, scientists discovered an important effect: enzymes that interact with chromatin stopped recognizing the “elderly” areas that could lead to malfunctions in the functioning of the cell.

Luis Herra, “This was a big surprise to us,” he explained. Luis Herra. – “Experience experience showed that chromatin is highly resistant to wear. However, when we focused on the processes affecting old areas, we have seen serious changes.

The scientist compared this with the work of the old computer: Some parts may function even if they are already incorrect. In other words, even if the individual components are damaged in the body, the overall structure remains effective.

Chemically creating “elderly” proteins and determining which wear leads to irreversible consequences, scientists hoped to find new approaches to the struggle against aging. His studies can help develop more effective drugs that can slow down age changes and restore cell functions.

Previously, scientists discovered Unique contacts between bacteria and human cells.

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Source: Gazeta

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