Scientists from Harvard Medical School, together with colleagues from the Max Delbrück Center for Molecular Medicine (Germany), have identified differences in the genetic activity of heart cells in people with various types of cardiomyopathy leading to the development of heart failure. The study was published in the journal Science.
The researchers analyzed samples from 61 patients with heart failure due to cardiomyopathy and 18 patients without any structural heart disease at the time of the study. The authors examined the activity of genes in ten types of heart cells. To do this, they used single-cell RNA sequencing (snRNA-seq).
Machine learning allowed them to identify patterns in gene activity in various types of cardiomyopathy, as well as in patients with or without heart failure. They found that all patients had an increased number of endothelial and immune cells. The number of connective tissue cells, the fibroblasts involved in scar formation, did not change, but gene activity changed dramatically in patients with heart failure.
Many cardiomyopathy that makes it difficult for the heart to pump blood, such as dilated cardiomyopathy (DCM) and arrhythmogenic cardiomyopathy (ACM), can lead to heart failure. However, the type of cardiomyopathy is not taken into account when treating patients with heart failure. The scientists’ work will allow the development of individual treatment for each type and screening of patients using inexpensive genotyping.
Source: Gazeta
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