Scientists from Johns Hopkins University in the USA discovered that people with diabetes accelerate the loss of white matter (tissue containing nerve fibers) in the brain. Research results It was published on JAMA Network.
185 people participated in the study, which lasted 27 years. The majority were white Europeans with higher education and a family history of dementia. Volunteers gave scientists access to their medical data and agreed to undergo multiple MRI brain scans.
During follow-up, 60 participants developed mild cognitive impairment (MCI) and eight were diagnosed with dementia. The results showed that the risk of MCI was 86% higher in people with greater white matter (nerve fiber) loss.
Further analysis showed that the amount of white matter in the brain was significantly reduced in people with type 2 diabetes. This resulted in a 41% increase in MCI risk.
The presence of dementia biomarkers in cerebrospinal fluid increased the likelihood of cognitive problems by 50%. Those at greatest risk were patients who also had diabetes and signs of amyloid plaques (protein aggregates that destroy neurons). Up to 55% were likely to develop mild cognitive impairment.
Scientists have suggested that the body’s inability to use insulin properly accelerates the accumulation of amyloid protein in the brain. This may trigger the development of Alzheimer’s disease and lead to a more rapid transition from a normal brain state to mild cognitive impairment.
Previously appearedthat normal sugar levels can slow brain aging.
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Source: Gazeta
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