Scientists from the University of Michigan Rogel Cancer Center found that the NSD2 protein alters the function of the androgen receptor, which regulates prostate development. This leads to rapid cell division and growth, causing prostate cancer. Research results It was published In the journal Nature Genetics.
Scientists explained that the androgen receptor usually determines the development of the prostate, stopping cell growth and maintaining the normal state of the organ. However, in cancer, the receptor acts differently, causing cells (including tumor cells) to continue to grow. The NSD2 protein plays an important role in this pathological process.
According to the researchers, the androgen receptor is usually found in certain regions of DNA. NSD2 changes the position of the androgen receptor on DNA, placing it near regions associated with cancer-causing genes.
During the experiment, scientists used various methods to reduce NSD2 activity in cancer cells. As a result, their growth and spread slowed down. It also turned out that another related protein, NSD1, could “help” NSD2 trigger the cancer cell proliferation process.
According to the researchers, developing specific NSD1/2 inhibitors could be an effective way to treat prostate cancer. They could also be combined with already approved drugs for a more powerful effect. Scientists have already begun creating such a drug, but it needs to undergo a series of clinical trials in mice before it can be used in humans.
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Source: Gazeta
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