Researchers from the VN Orekhovich Institute of Biomedical Chemistry (IBMH) together with colleagues from the MM Krasnov Institute of Eye Diseases linked the development of age-related macular degeneration with the length of telomeres – special proteins at the ends of chromosomes. The Ministry of Education and Science of the Russian Federation told socialbites.ca about this.
Age-related macular degeneration (AMD) is a chronic, progressive eye disease that most often occurs in older adults. This disease affects the retina and causes the person to see worse.
Many scientists believe that the cause of this disease is related to the work of white blood cells, which are cells of the immune system. Therefore, IBMH decided to study a mixture of white blood cells, consisting of different cells. From this mixture, scientists isolated all cell subtypes and examined the length of telomeres (a marker of cellular aging of white blood cells) in each of them. Thus, it was possible to establish that the length of telomeres in immune cells and monocytes correlates very well with the development of various forms of AMD.
“Telomers are ordered nucleotide sequences located at the ends of human chromosomes, protecting them from damage and ensuring their normal functioning. The longer the telomeres, the more stable the chromosomes. Conversely, the shorter the telomeres, the less active the chromosomes and cells are. Comparing our data with the clinical manifestations of AMD, we can talk about the involvement of monocytes in the pathogenesis of this disease. “Based on our results, we plan to devote further work to the development of diagnostic methods,” Dmitry Zhdanov, head of the IBMH RAND laboratory, told socialbites.ca.
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Source: Gazeta
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