Molecules that protect the intestines have been discovered 21:37

Scientists from the Institute of Biology of the State University of Campinas (Brazil) have discovered that inhibitory molecules that suppress a specific protein called IL-22BP can have a positive effect on the intestinal microbiome and increase resistance to infections. published In the journal Proceedings of the National Academy of Sciences (PNAS).

In experiments on mice, the researchers found that IL-22BP (a protein that binds to interleukin 22) reduced the amount of IL-22 protein needed to maintain a healthy intestinal barrier, strengthen intestinal lining cells, and produce antimicrobial substances. Rodents lacking IL-22BP showed increased protection against intestinal infections caused by the bacteria Clostridioides difficile and Citrobacter rodentium.

To find out whether it is possible to artificially strengthen intestinal immunity, scientists transplanted intestinal bacteria from mice lacking IL-22BP into normal rodents. As a result, the latter acquired resistance to Clostridioides difficile and Citrobacter rodentium.

The researchers explained that beneficial changes in the microbiota are due to increased production of short-chain fatty acids in the absence of IL-22B. These acids have a positive effect on the condition of the intestines, creating an anti-inflammatory environment and strengthening the mucosal barrier of the organ. These acids are produced by intestinal bacteria as a result of fermentation of dietary fiber.

Future studies will evaluate the effectiveness of IL-22BP inhibitors in animals and in clinical trials for treating serious intestinal infections, the scientists said, and will also examine how different types and amounts of dietary fiber affect the formation of short-chain fatty acids.

Previously found The relationship between gastrointestinal diseases and damage to cerebral vessels.