A new cause of calcium deposition in the aorta was found 06/09/2024, 22:42

In Alzheimer’s disease, toxic amyloid protein clumps form in the brain. In a new study, scientists found that its buildup in the aorta (the largest blood vessel) contributes to its narrowing. The results of the research were published in the journal Cell Trends in Molecular Medicine.

When the aortic valve calcifies, microcrystals of the hydroxyapatite mineral accumulate in it. This leads to deterioration of heart functions. Once the disease is diagnosed, most patients do not survive more than two years. The only treatment is aortic valve replacement, and this is not suitable for every patient.

In a new study, scientists used electron microscopy to detect amyloid protein in the tissue of patients’ aortic valves. They suggest that high levels of “bad” cholesterol (LDL) may create conditions for amyloid deposition. This forms the basis of hydroxyapatite crystals.

This discovery could mean that drugs that fight amyloid buildup could be useful not only for Alzheimer’s disease but also for people with aortic valve calcification.

Formerly an ingredient of toothpaste connected with an increased risk of stroke and heart attack.

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Source: Gazeta


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