Berberine, a compound found in barberry, has been shown to inhibit the spread of cancer cells in lung tissue, at least in vitro. Pharmacologists from Sydney University of Technology and colleagues from Saudi Arabia, Malaysia and India report this in an article in the journal Science. medicine.
Cell culture experiments have shown that berberine increases the activity of genes that produce substances that inhibit tumor growth and reduces the level of proteins important for the migration and survival of cancer cells. In addition, berberine was able to reduce lung cell damage caused by tobacco smoke exposure and inflammation, which increases the risk of cancer and other lung diseases.
“Berberine has shown therapeutic benefits in diabetes and cardiovascular disease. Researchers wanted to explore its potential to suppress lung cancer and reduce inflammation,” he said.
Despite the promising results from previous studies, the use of berberine has been problematic due to its low water solubility and poor intestinal absorption, as well as its toxicity at high doses. The scientists managed to circumvent this limitation by encapsulating berberine molecules in special capsules made of liquid crystal nanoparticles. In the future, the researchers plan to continue working on this method so that berberine can be used in medicine.
Source: Gazeta
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