American scientists from the University of Massachusetts at Amherst have described a way to fight cancer using routine vaccines that many people receive as part of routine vaccinations in childhood. To work published In the scientific journal Frontiers in Immunology (FI).
Experts have suggested placing the protein antigen from a standard vaccine into a malignant tumor, making it a target for the immune system. Experts plan to use a safe form of salmonella as a way to deliver the antigen into the tumor.
To test their theory, the team genetically modified Salmonella bacteria to deliver ovalbumin (chicken egg white) to pancreatic tumor cells in mice vaccinated with the ovalbumin vaccine. It turned out that the protein spreads throughout the cytoplasm of cells of both healthy tissues and tumors.
Ovalbumin triggered an antigen-specific response from immune cells that then attacked cancers in the cytoplasm. The therapy eliminated 43% of pancreatic tumors, improved survival, and prevented tumor reimplantation; Three of the seven mice made a full recovery.
Scientists were unable to grow new tumors in vaccinated rodents because their immune systems began to reject the cancer cells.
Experts hope that the method they have developed will make it possible to fight difficult-to-treat types of liver cancer, as well as breast and pancreatic cancer.
Previous scientists developed A new way to predict lung cancer in smokers.
Source: Gazeta
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