Scientists at the H. Lee Moffit Cancer Center and Research Institute found that women who survived breast cancer grew faster at biological age compared to women without cancer. This effect has been associated with a particular treatment method. Research published Journal of the National Cancer Institute.
The analysis included data from 190 women who donated blood twice, five to ten years apart. During this time, she was diagnosed and treated for breast cancer. Their results were compared with those of women of the same age who did not have cancer.
Each blood sample was analyzed using three biological age indicators: PhenoAgeAccel, GrimAgeAccel and DunedinPACE. Special tags of the DNA molecule (methylation tags) are used to evaluate these indicators.
The analyzes showed that women treated for breast cancer between blood draws experienced a faster increase in biological aging compared to those without cancer. The rate of biological aging was highest in those who received radiation therapy compared to those who received endocrine therapy or chemotherapy and radiation therapy.
One in eight women will develop breast cancer in their lifetime. The disease is curable, especially if detected early. The scientists’ results could help improve the effectiveness of breast cancer treatment and subsequent recovery.
“Breast cancer survivors have a higher incidence of various age-related diseases, including cardiovascular disease, and experience faster physical and cognitive aging than women without a history of breast cancer. In this study, we wanted to investigate the underlying biology and find out which cancer treatments have the greatest long-term impact on survivors,” the scientists explained.
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Source: Gazeta
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