Chinese scientists from biotechnology company InSilico Medicine have discovered a new drug to treat anemia. This breakthrough was achieved thanks to the artificial intelligence (AI)-based Chemistry42 platform, which consists of more than 40 artificial intelligence models. The study was published in the scientific journal magazine Journal of Medicinal Chemistry (JMC).
Neural network discovers a new prolyl hydroxylase inhibitor (PHD). This compound affects fundamental biological processes, including red blood cell production, indicating the potential to combat anemia in chronic kidney disease.
Using built-in filters including drug similarity, synthesis score, and more, the AI analyzed various PHD inhibitor options until determining the optimal combination.
Tests on rats showed that the resulting substance alleviated anemia in rodents. It is also relatively easy to synthesize.
“Thanks to Chemistry42, we have received comprehensive assistance from molecular fabrication to compound selection. With the help of generative AI, we can accelerate the drug discovery process without affecting its novelty or quality,” said computational chemist Xiaoyu Ding, first author of the study.
happened before knownThat artificial intelligence can predict human life expectancy.